Antiangiogenesis in prostate cancer Review Article

Metastatic prostate cancer is the second leading cause of cancer related death. While androgen ablation is an effective initial modality, progression of disease is eventually occurred in majority patients. The benefit of chemotherapy in overall survival is still unclear. Angiogenesis plays a pivotal role for the growth, invasion, and metastasis of prostate cancer. Therefore, antiangiogenesis is a promising new therapeutic modality. Currently, there are more than 20 antiangiogenic agents in various stages of clinical trials. We will discuss current knowledge on controlling tumor angiogenesis and advances in the development of antiangiogenic agents with promising antitumor activity in prostate cancer.